Reproductive toxicity of sodium valproate in male rats
نویسندگان
چکیده
منابع مشابه
Ellagic acid modulates sodium valproate induced reproductive toxicity in male Wistar rats.
This study evaluated the protective effect of ellagic acid on sodium valproate-induced sperm abnormalities in male Wistar rats. A total of 30 rats were grouped into five groups, each having 6 animals. Vehicle, sodium valproate (400 mg/kg) and ellagic acid (10, 25, 50 mg/kg) were given orally from day 1 to day 7, and ellagic acid was continued for 3 more days. On day fourteen, animals were sacri...
متن کاملThe effect of sodium valproate on sex hormones in male rats
Background & Aim: Sodium valproate is one of the most common antiepileptic drugs used in the first line of treatment for epilepsy, bipolar disorder, mood disorders, and more recently, as an anticancer drug. The occurrence of seizures and the use of Sodium valproate both have sexual and hormonal side effects and ultimately cause infertility in males. In previous studies, the definitive effects o...
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15 صفحه اولEvaluation of reproductive and renal toxicity of varenicline in male rats
Objective(s): Varenicline is a selective partial agonist for the nicotinic acetylcholine receptor a4b2 subtype, which is widely used to treat smoking addiction. However, there is still no data about its potential toxic effects on tissues. In this study, we aimed to determine the varenicline-induced toxicity on reproductive and renal tissues in rats.Ma...
متن کاملThe effect of sodium valproate on the biochemical parameters of reproductive function in male albino Wistar rats
OBJECTIVE To assess the effects of sodium valproate on intratesticular testosterone and lactic dehydrogenase level in rats. METHODS Male Wistar rats (12 weeks old) were treated with sodium valproate and sacrificed at the end of the 2(nd), 4(th), 5(th), 7(th), 10(th) and 15(th) week, after the last exposure to sodium valproate. The testes were removed, weighed and processed for biochemical ana...
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ژورنال
عنوان ژورنال: Indian Journal of Pharmacology
سال: 2010
ISSN: 0253-7613
DOI: 10.4103/0253-7613.64503